Nanospheres Safely Deliver High Chemotherapy Doses in Response to Tumor Secretions

Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize. That is, they have engineered a drug delivery system so that the very enzymes that make cancers dangerous could instead guide their destruction.

“We can start with a small molecule and build that into a nanoscale carrier that can seek out a tumor and deliver a payload of drug,” said Cassandra Callmann, a graduate student in chemistry and biochemistry at the University of California, San Diego, and first author of the report published in the journal Advanced Materials July 14. …Read the full story from the UC San Diego News Center

Jill P. Mesirov Appointed Associate Vice Chancellor for Computational Health Sciences

UC San Diego School of Medicine recruits world leader in computational biology —

Leading computational biologist Jill P. Mesirov, PhD, has been appointed associate vice chancellor for computational health sciences and professor of medicine at University of California, San Diego School of Medicine and Moores Cancer Center. Mesirov most recently served as associate director and chief informatics officer at the Broad Institute of MIT and Harvard, where she directed the Computational Biology and Bioinformatics Program. … Read the full story from the UC San Diego Newsroom


Dr. Mesirov joins the Department of Medicine as a professor in the Division of Medical Genetics.

Clinical Trial Launched to Assess Safety and Efficacy of Autism Drug Treatment

UC San Diego researchers open first study of suramin in children with autism —

Researchers at the University of California, San Diego School of Medicine have launched a clinical trial to investigate the safety and efficacy of an unprecedented drug therapy for autism.

The phase 1 clinical trial, which is recruiting 20 qualifying participants, will evaluate suramin – a century-old drug still used for African sleeping sickness – as a novel treatment for children with a diagnosis of Autism Spectrum Disorder (ASD). Previous published research by Robert K. Naviaux, MD, PhD, professor of medicine, pediatrics and pathology at UC San Diego School of Medicine, and colleagues reported that a single injection of suramin reversed symptoms of ASD in mouse models. …Read the full story from the UC San Diego Newsroom


Robert Naviaux, MD, PhD, is professor of medicine in the Division of Medical Genetics and professor in the departments of pediatrics and pathology.

He co-directs the Mitochondrial and Metabolic Disease Center at UC San Diego.

More about research in the Naviaux laboratory

Clinical Trial Launched to Assess Safety and Efficacy of Autism Drug Treatment

UC San Diego researchers open first study of suramin in children with autism —

Researchers at the University of California, San Diego School of Medicine have launched a clinical trial to investigate the safety and efficacy of an unprecedented drug therapy for autism.

The phase 1 clinical trial, which is recruiting 20 qualifying participants, will evaluate suramin – a century-old drug still used for African sleeping sickness – as a novel treatment for children with a diagnosis of Autism Spectrum Disorder (ASD). Previous published research by Robert K. Naviaux, MD, PhD, professor of medicine, pediatrics and pathology at UC San Diego School of Medicine, and colleagues reported that a single injection of suramin reversed symptoms of ASD in mouse models. …Read the full story from the UC San Diego Newsroom


Senior author Robert K. Naviaux, MD, PhD, is professor of medicine in the Division of Medical Genetics. He co-directs the Mitochondrial and Metabolic Disease Center at UC San Diego.

Visit the Naviaux Laboratory website

Researchers Boost Body’s Inflammation-Reduction Mechanism to Combat Obesity-Fueled Disease

Researchers at University of California, San Diego School of Medicine and University College Dublin (UCD) have found that augmenting a naturally occurring molecule in the body can help protect against obesity-related diseases by reducing inflammation in the fat tissues. The study, published June 4 in the journal Cell Metabolism, focused on liver and kidney diseases, but the researchers believe it could lead to a new therapeutic approach for a variety of obesity-fueled conditions.

“This is a new way of reducing inflammation and protecting organs, using a compound that’s already produced by the body,” said co-senior author Kumar Sharma, MD, a professor of medicine and director of the Center for Renal Translational Medicine at UC San Diego School of Medicine. “Essentially, we’re boosting the body’s natural response for reducing inflammation and showing the benefit in obesity-driven diseases.” … Read the full story from the UC San Diego Newsroom

Dr. Tyler Woodell and Dr. Lawrence Ma Receive Arnold P. Gold Foundation’s Humanism and Excellence in Teaching Resident Awards

Dr. Tyler Woodell

Tyler Woodell, MD

Tyler Woodell, MD, left, a senior categorical internal medicine resident, and Lawrence Ma, MD, a fourth-year medicine-pediatrics resident, will receive the Arnold P. Gold Foundation’s Humanism and Excellence in Teaching Resident Award in a ceremony at the UC San Diego School of Medicine on May 15.

The award recognizes Dr. Woodell and Dr. Ma as role models for others in their compassion, dedication and humanism in their approach to patient care.

Dr. Lawrence Ma

Lawrence Ma, MD

“The Gold Humanism and Excellence in Teaching Resident Award is one of the greatest honors that can be bestowed upon a resident,” said internal medicine residency program director Dr. Simerjot Jassal. “Tyler is a beacon of professionalism. I think this is the most important quality a physician can possess.”

Simerjot K. Jassal, MD, MAS, FACP, is clinical professor in the Department of Medicine.

“This is a great honor that is given to only a handful of UC San Diego housestaff each year. Congratulations to both Lawrence and Tyler!” said Lori Wan, MD, director of the Combined Medicine/Pediatrics Residency Program. She is clinical professor of medicine and pediatrics.

Drs. Woodell and Ma were selected in a vote by third-year medical students and each is one of six recipients this year.

After graduating from the UC San Diego Internal Medicine Residency Training Program in June, Dr. Woodell will begin fellowship training in nephrology at Oregon Health and Science University.

Dr. Ma will start a fellowship in geriatrics at Stanford University in July, with the ultimate goal of practicing primary care across the age spectrum.

As award recipients, Dr. Woodell and Dr. Ma become lifetime members of the UC San Diego Gold Humanism Honor Society. One of their first actions as awardees is to speak to the rising third-year medical students at UC San Diego during Clinical Transition Week.

Researchers Discover Protein’s Pivotal Role in Heart Failure

Better understanding of molecular mechanism could lead to new drug targets —

Researchers at the University of California, San Diego School of Medicine have identified a key piece in the complex molecular puzzle underlying heart failure – a serious and sometimes life-threatening disorder affecting more than 5 million Americans.

In a study published in the March 5 online issue of Cell Reports, Xiang-Dong Fu, PhD, and colleagues explored the heart’s progression from initial weakening to heart failure, and found that a protein, known as RBFox2, plays a critical role in this process. … Read the full story from the UC San Diego Newsroom


Ju Chen, PhD

Ju Chen, PhD

A number of Division of Cardiovascular Medicine researchers and affiliates are coauthors, including Kunfu Ouyang, Indroneal Banerjee, PhD; Caimei Zhang, Biyi Chen, Ju Chen, PhD; and Long-Sheng Song.

Dr. Chen is Professor of Medicine, American Heart Association Endowed Chair in Cardiovascular Research and Director of Basic Cardiac Research at University of California, San Diego School of Medicine.

Senior author Xiang-Dong Fu, PhD, is professor in the Department of Cellular and Molecular Medicine and investigator in the Institute of Genomic Medicine at UC San Diego.

See Full Text of Article (open access)

Division of Regenerative Medicine Holds First Research Symposium

Catriona H. M. Jamieson, MD, PhD

Dr. Catriona Jamieson

On Friday, January 30, the Division of Regenerative Medicine presented its inaugural symposium on novel research and technologies in regenerative medicine.

The meeting featured scientific presentations by world-renowned academic investigators and industry leaders as well as a discussion panel including keynote speakers Dr. Hans Clevers, Dr. Derrick Rossi, Dr. Carl June and Dr. Wolfgang Dillmann.

Division Chief Catriona Jamieson, MD, PhD, presented the mission and milestones of the new Division of Regenerative Medicine after introductions from UC San Diego Chancellor Pradeep Khosla; Vice Chancellor Health Sciences and Dean of UC San Diego School of Medicine Dr. David Brenner; and Chief Executive Officer of UC San Diego Health System and Associate Vice Chancellor of UC San Diego Health Sciences Paul Viviano.

UC San Diego Moores Cancer Center

UC San Diego Moores Cancer Center

Catriona Jamieson, MD, PhD, is associate professor in the Division of Hematology-Oncology, deputy director of the Sanford Stem Cell Clinical Center, chief of the Division of Regenerative Medicine and director of stem cell research at the Moores Cancer Center.

UC San Diego School of Medicine Named One of Nation’s Top Residency Programs

Recognized by physicians for training leadership in Doximity report — 

UC San Diego School of Medicine was today named one of the nation’s top residency training programs in 10 specialties by Doximity. The Doximity report included more than 50,000 peer nominations from board-certified US physicians, and evaluated 3,691 residency training programs across 20 specialties.

“One of the most important functions of our academic health system is residency training for the next generation of physicians. The outstanding training of our residents guarantees great future physicians for San Diego and beyond,” said David A. Brenner, MD, vice chancellor for Health Sciences and dean of the UC San Diego School of Medicine.

UC San Diego School of Medicine placed in the top 10 for residency training in the West in the following specialties: internal medicine, anesthesiology, dermatology, obstetrics & gynecology, orthopaedic surgery, otolaryngology, pediatrics, psychiatry, radiology (diagnostic) and surgery. More than 900 post-graduate trainees, including interns, residents and fellows, train at UC San Diego each year…. Read the full story from the UC San Diego Newsroom


Dr. Simerjot Jassal

Dr. Simerjot Jassal

Simerjot Jassal, MD, MAS, FACP, pictured at left, directs the Internal Medicine Residency Training Program and its Preliminary Medicine track.

Dr. Jassal is clinical professor in the Department of Medicine.

Dr. Mark Ginsberg

Dr. Mark Ginsberg

Mark Ginsberg, MD, professor of medicine, directs the program’s research track, the Physician-Scientist Training Program.

In other Department of Medicine-related training, UC San Diego School of Medicine placed in the top 10 for residency training in anesthesiology, dermatology and pediatrics.

Dr. Jassal co-directs a new Combined Medicine-Anesthesia program track of the Internal Medicine Residency Training Program with Daniel Lee, MD, PhD, associate clinical professor of anesthesiology and pediatrics.

Dr. Lori Wan

Dr. Lori Wan

A Combined Medicine-Pediatrics Training Program track of the internal medicine program is directed by Lori Wan, MD, clinical professor of medicine.

Also rated in the top 10 is UC San Diego’s Dermatology Residency Training Program, directed by dermatology division chief Richard L. Gallo, MD, PhD, and Casey Carlos, MD, PhD, pictured below.

Dr. Gallo is professor of medicine and pediatrics and Dr. Carlos is assistant clinical professor in the Division of Dermatology in the Department of Medicine.

Dr. Richard Gallo

Dr. Richard Gallo

Casey Carlos, MD, PhD

Dr. Casey Carlos

 

 

 

First Angioedema Treatment Center Opens at UC San Diego Health System

UC San Diego Health System in partnership with the U.S. Hereditary Angioedema Association (HAEA), a non-profit patient advocacy organization, has opened the nation’s first dedicated center for diagnosing and treating diverse forms of swelling, known collectively as angioedema.

The U.S. HAEA Angioedema Center at UC San Diego Health System will serve as an international referral center for people with all types of angioedema and will work closely with basic science laboratories at UC San Diego School of Medicine to better understand the condition and develop new treatments. … Read the full story from the UC San Diego Newsroom


Dr. Bruce Zuraw

Dr. Bruce Zuraw

Bruce Zuraw, MD, professor of medicine and chief of the Division of Rheumatology, Allergy and Immunology, is the U.S. HAEA Angioedema Center’s director and the inaugural recipient of the U.S. HAEA Endowed Chair at UC San Diego.  |  Dr. Zuraw’s clinical profile

Dr. Marc Riedl

Dr. Marc Riedl

Marc Riedl, MD, MS, associate professor of medicine, is the Center’s clinical director.  |  Dr, Riedl’s clinical profile