Using microRNA Fit to a T (cell)

Researchers show B cells can deliver potentially therapeutic bits of modified RNA

Researchers at the University of California, San Diego School of Medicine have successfully targeted T lymphocytes – which play a central role in the body’s immune response – with another type of white blood cell engineered to synthesize and deliver bits of non-coding RNA or microRNA (miRNA). … Read the full story from the UC San Diego News Center

Dr. Maurizio ZanettiPrincipal investigator Maurizio Zanetti, MD, is emeritus professor of medicine in the Division of Hematology-Oncology and director of the Laboratory of Immunology at the UCSD Moores Cancer Center.

Dr. Zanetti is the director of tumor immunology for the UCSD Center for Immunology, Infection and Inflammation. He directs the immunology course in the Biomedical Sciences graduate program.

Citation for the study report in Proceedings of the National Academy of Sciences:

Gonzalo Almanza, Veronika Anufreichik, Jeffrey J. Rodvold, Kevin T. Chiu, Alexandra DeLaney, Johnny C. Akers, Clark C. Chen, and Maurizio Zanetti. Synthesis and delivery of short, noncoding RNA by B lymphocytes. PNAS 2013 ; published ahead of print November 25, 2013, doi:10.1073/pnas.1311145110  |  Abstract (Open access)  |  Full text (UCSD only)

Other UCSD news stories about Dr. Zanetti’s work:

New Study Upends Thinking About How Liver Disease Develops

In the latest of a series of related papers, researchers at the University of California, San Diego School of Medicine, with colleagues in Austria and elsewhere, present a new and more definitive explanation of how fibrotic cells form, multiply and eventually destroy the human liver, resulting in cirrhosis… Read the full story from the UCSD Newsroom

Pictured above is David Brenner, MD, Vice Chancellor for Health Sciences and dean of the UC San Diego School of Medicine, who is senior author of the research report.  First author of the study is Dr. Christoph H. Österreicher of the Biomedical Genomics (BIOGEM) Microarray Facility in the UCSD Department of Medicine, the Laboratory of Gene Regulation and Signal Transduction in the UCSD Department of Pharmacology, and the Medical University of Vienna. Other Department of Medicine coauthors are Drs. Melitta Penz-Österreicher (Medical University of Vienna), Roman Šášik, and BIOGEM director Dr. Gary Hardiman.

Read the report in the Proceedings of the National Academy of Sciences.

Researchers Describe First Functioning “Lipidome” of Mouse Macrophage

For the first time, scientists have described not only the identities and quantities of fat species in a living mammalian cell – in this case, a mouse macrophage or white blood cell – but they also report how these lipids react and change over time … Read the full story from the UCSD Newsroom

Dr. Gary Hardiman

Three coauthors of the research report in the Journal of Biological Chemistry are members of the Division of Endocrinology and Metabolism in the Department of Medicine: Oswald Quehenberger, Ph.D., Professor of Medicine; Christopher K. Glass, M.D., Ph.D., Professor of Medicine and Professor of Cellular and Molecular Medicine; and Gary Hardiman, Ph.D. (pictured above), Associate Professor of Medicine and Director of the Biomedical Genomics Microarray Facility.