Study Finds Psoriasis Drug Significantly Effective in Treating Crohn’s Disease

Researchers at University of California San Diego School of Medicine have shown that ustekinumab, a human antibody used to treat arthritis, significantly induces response and remission in patients with moderate to severe Crohn’s disease. Results of the clinical trial will appear in the November 16 issue of the New England Journal of Medicine.

“A high percentage of the patients in the study who had not responded to conventional therapies were in clinical remission after only a single dose of intravenous ustekinumab,” said William J. Sandborn, MD, professor of medicine at UC San Diego School of Medicine and director of the Inflammatory Bowel Disease Center at UC San Diego Health. … Read the Full Story from the UC San Diego Newsroom


Dr. William Sandborn

William J. Sandborn, MD

William A. Sandborn, MD, is chief of the Division of Gastroenterology in the Department of Medicine.

Study Shows Ozanimod as Effective in Treating Ulcerative Colitis

Researchers at University of California San Diego School of Medicine have shown that ozanimod (RPC1063), a novel drug molecule, is moderately effective in the treatment of ulcerative colitis. Results of the Phase II clinical trial will appear in the May 5 issue of the New England Journal of Medicine.

“This new class of immunotherapy drug traps white blood cells in the lymph nodes to prevent their escape into the gut where they cause inflammation,” said William J. Sandborn, MD … Read the Full Story from the UC San Diego Newsroom


Dr. William Sandborn

Dr. William Sandborn

William Sandborn, MD, is Professor of Medicine and Chief of the Division of Gastroenterology and Hepatology at UC San Diego.

Read the article abstract in the New England Journal of Medicine.

Four Department of Medicine Faculty Members Are on 2015 Thomson Reuters Highly Cited Researchers List

Dr. William Sandborn

William Sandborn, MD

Four UC San Diego Department of Medicine researchers are among the most influential researchers in the world, according to the 2015 Thomson Reuters Highly Cited Researchers list.

They are , William Sandborn, MDDon W. Cleveland, PhD, Lewis J. Rubin, MD, and Sergei L. Kosakovsky Pond, PhD.

Dr. Don W. Cleveland

Don W. Cleveland, PhD

Dr. Sandborn is Professor and Chief of the Division of Gastroenterology & Hepatology.

Dr. Cleveland is Chair of the Department of Cellular and Molecular Medicine and Distinguished Professor of Medicine, Cellular and Molecular Medicine, and Neurosciences.

Sergei L. Kosakovsky Pond, PhD

Sergei L. Kosakovsky Pond, PhD

Dr. Pond, Associate Professor of Medicine, is a specialist in infectious disease with a focus on developing software models of evolving pathogens such as HIV and hepatitis C virus.

Dr. Rubin, whose research addresses pulmonary vascular disease and pulmonary arterial hypertension, is Professor of Medicine, Emeritus, in the Division of Pulmonary, Critical Care & Sleep Medicine.

Lewis Rubin, MD

Lewis Rubin, MD

With 165 faculty members on the latest edition of the list, the UC System ranks first in the world on the list of highly cited researchers.

Each year, Thomson Reuters uses citation analysis to identify the world’s most influential contemporary scientists. The 2015 list, encompassing publications from 2003 to 2013, contains more than 3,100 names.

More on the UC System’s achievement from the UC Office of the President

See the names of all UC System faculty members on the list

More about the list and the methodology from Thomson Reuters

View a searchable database of the researchers

Researchers Find Link Between Inflammation, Tissue Regeneration and Wound Repair Response

Discovery has implications for potential new treatments of some cancers and inflammatory bowel disease —

Almost all injuries, even minor skin scratches, trigger an inflammatory response, which provides protection against invading microbes but also turns on regenerative signals needed for healing and injury repair – a process that is generally understood but remains mysterious in its particulars.

Writing in the February 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130.. … Read the full story from the UC San Diego Newsroom


Dr. William SandbornStudy coinvestigators included Division of Gastroenterology division chief William Sandborn, MD, and Inflammatory Disease Center researchers Brigid S. Boland and John T. Chang.

Other Department of Medicine coauthors included Petrus R. de Jong; and Samuel B. Ho, professor of medicine in the Division of Gastroenterology and Section Chief, Gastroenterology, at the VA San Diego Healthcare System.

Full text of the article (UC San Diego only)

Dr. Sheila Crowe Selected as Vice President of the American Gastroenterological Association

An Announcement from Dr. William J. Sandborn
Professor and Chief, Division of Gastroenterology –

Dr. William Sandborn

Dr. William Sandborn

It is with great pleasure that I share with you that Dr. Sheila Crowe has been selected as Vice President of the American Gastroenterological Association (AGA).

In this role, she will begin a four-year term of service to the AGA, transitioning yearly from Vice President to President Elect to President and finally to Past President and Chair of the AGA Foundation.

Dr. Sheila E. Crowe

Dr. Sheila E. Crowe, Professor of Medicine and Director of Research in the Division of Gastroenterology.

This is perhaps the highest honor that a physician in our specialty can receive. It is a tremendous honor for Dr. Crowe, and for our entire Division.

I am so proud to have Dr. Crowe in our Division. Please join me in congratulating her on this accomplishment.

Best regards,

William J. Sandborn, MD
Professor of Medicine and Adjunct Professor of Surgery
Chief, Division of Gastroenterology
Director, Inflammatory Bowel Disease Center
University of California, San Diego
and UC San Diego Health System

Study Finds Potential New Drug Therapy for Crohn’s Disease

Ustekinumab Induces, Sustains Clinical Response in Patients

Ustekinumab, an antibody proven to treat the skin condition psoriasis, has now shown positive results in decreasing the debilitating effects of Crohn’s Disease, according to researchers at the University of California San Diego, School of Medicine. The study will appear in the October 18, 2012 issue of the New England Journal of MedicineRead the full story from the UCSD Newsroom


Dr. William J. SandbornThe principal investigator of the study is Dr. William J. Sandborn, professor of medicine and chief of the Division of Gastroenterology at UCSD.  |  Read his academic profile  |  Read his clinical profile

Read the report of the study in the New England Journal of Medicine (full text UCSD only)

Citation of study report:  Sandborn WJ, Gasink C, Gao L-L, Blank MA, Johanns J, Guzzo C, Sands BE, Hanauer SB, Targan S, Rutgeerts P,  Ghosh S, de Villiers WJS, Panaccione R, Greenberg G, Schreiber S, Lichtiger S, Feagan BG for the CERTIFI Study Group. N Engl J Med 2012; 367:1519-1528 October 18, 2012 DOI: 10.1056/NEJMoa1203572

Dr. Timothy Bigby Receives Department of Medicine Clinical Services Award for 2011-2012

Dr. Timothy BigbyDr. Timothy Bigby, professor of medicine and interim chief of the Division of Pulmonary & Critical Care Medicine, has received the Department of Medicine’s Leadership & Innovation in Patient-Centered Systems award for 2011-2012.

Each year, the award recognizes the clinical program leader whose efforts have achieved particular excellence in service of the patient care mission in internal medicine and its subspecialties.

“Physician leaders in the Department of Medicine are contributing in extremely significant ways. Dr. Bigby’s recognition speaks to the magnitude of his accomplishments above and beyond the already high standards,” said Dr. Daniel Bouland, clinical professor of medicine and Vice Chair for Clinical Operations in the Department of Medicine.

Drs. Daniel Bouland, Timothy Bigby and Francis Gabbai

Pictured above: Leadership & Innovation in Patient-Centered Systems Award recipient Timothy Bigby, MD, with Daniel Bouland, MD, at left and Francis Gabbai, MD, at right. Dr. Gabbai is Chief of the Medicine Service at the VA San Diego Healthcare System and Professor and Vice Chair for VA Affairs in the Department of Medicine.
A highlight of Medicine’s end-of-year clinical services meeting was a panel discussion with three UC San Diego Health System internal medicine physicians whose clinical programs deliver five-star service.

The panelists: