Researchers Discover Protein’s Pivotal Role in Heart Failure

Better understanding of molecular mechanism could lead to new drug targets —

Researchers at the University of California, San Diego School of Medicine have identified a key piece in the complex molecular puzzle underlying heart failure – a serious and sometimes life-threatening disorder affecting more than 5 million Americans.

In a study published in the March 5 online issue of Cell Reports, Xiang-Dong Fu, PhD, and colleagues explored the heart’s progression from initial weakening to heart failure, and found that a protein, known as RBFox2, plays a critical role in this process. … Read the full story from the UC San Diego Newsroom

Ju Chen, PhD

Ju Chen, PhD

A number of Division of Cardiovascular Medicine researchers and affiliates are coauthors, including Kunfu Ouyang, Indroneal Banerjee, PhD; Caimei Zhang, Biyi Chen, Ju Chen, PhD; and Long-Sheng Song.

Dr. Chen is Professor of Medicine, American Heart Association Endowed Chair in Cardiovascular Research and Director of Basic Cardiac Research at University of California, San Diego School of Medicine.

Senior author Xiang-Dong Fu, PhD, is professor in the Department of Cellular and Molecular Medicine and investigator in the Institute of Genomic Medicine at UC San Diego.

See Full Text of Article (open access)

Roche Funds Drug Discovery Projects at UC San Diego

The new UC San Diego-Roche Extending Innovation Network (EIN) program has been launched with selection of its first three research projects at the University of California, San Diego School of Medicine. The UC San Diego-Roche EIN program, which was formalized in June 2011, aims to accelerate the discovery of new drug therapies through research innovation at the interface of industry and academia. The program is slated to grow in the coming years as additional rounds of proposals are solicited. … Read the full story from the UCSD Newsroom

M. Geoffrey Rosenfeld, MD
M. Geoffrey Rosenfeld, MD (pictured above), is a co-investigator with Xiang-Dong Fu, PhD, on one of the three UC San Diego-Roche EIN-funded projects, in which the investigators will use genomic and RNA-based approaches to identify new drug targets.

Dr. Rosenfeld is Professor of Medicine in the Division of Endocrinology and Metabolism and a professor of the Howard Hughes Medical Institute. Dr. Fu is Professor of Cellular and Molecular Medicine and a member of the Institute for Genomic Medicine.